| Application | Intermediates offered | CAS# |
|---|---|---|
| Afoxolaner | Methyl 4-acetyl-1-naphthoate 4-Acetyl-1-napthoic acid | 501441-64-1 131986-05-5 |
| Antrazoline | 2-(Chloromethyl)-4,5-dihydro-1H-imidazole HCl | 13338-49-3 |
| Aminolevulinic acid | Methyl Succinyl Chloride | 1490-25-1 |
| Apremilast | 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine S-1-(3-Ethoxy-4-Methbxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-Leucine 3-Aminophthalic acid 3-Acetamidophthalic anhydride | 253168-94-4 608141-43-1 5434-20-8 6296-53-3 |
| Atracurium/Cisatracurium Besylate | Tetrahydropapaverine hydrochloride Dihydropapaverine HCl | 6429-04-5 5884-22-0 |
| Azathioprine | 6-Mercaptpurine monohydrate 5-Chloro-4-Nitro-1-Methylimidazole | 6112-76-1 4897-25-0 |
| Azelnidipine | 3-Amino-3-iminopropanoic acid 1-(diphenylmethyl)-3-azetidinyl ester acetate Isopropyl 2-(3-Nitrobenzylidene)acetoacetate | 170749-59-4 39562-25-9 |
| Bempedoic acid | Ethyl-2,2-dimethyl-7-bromoheptanoate 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid diethyl ester 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid | 123469-92-1 738606-43-4 413624-71-2 |
| Benzydamine | 1-Benzyl-3-hydroxy-1H-indazole 1-Benzyl-3-hydroxy-1H-indazole Sodium Salt | 2215-63-6 13185-09-6 |
| Betaxolol | 2-(4-Benzyloxyphenyl) ethanol | 61439-59-6 |
| Betrixaban | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 4-[(Dimethylamino)iminomethyl]benzoic acid HCl | 280773-17-3 210963-78-3 |
| Bilastine | 2-[4-[1-(4,4-dimethyl-5H-oxazol-2-yl)-1-methyl-ethyl]phenyl]ethanol p-Toluenesulfonate 2-[4-[1-(4,4-dimethyl-5H-oxazol-2-yl)-1-methyl-ethyl]phenyl]ethanol 2-(4-piperidyl)-1h-1,3-benzimidazole 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride 2-Ethoxyethyl 4-Toluenesulfonate "2-(1-(4-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-y l)propan-2-yl)phenethyl)piperidin-4-yl)- 1-(2-ethoxyethyl)-1H-benzo[d]imidazole 2-(4-Bromophenyl)-2-methylpropionic acid Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate | 202189-76-2 361382-26-5 38385-95-4 1841081-72-8 17178-11-9 202189-77-3 32454-35-6 154825-97-5 |
| Brigatinib | 5-Fluoro-2-nitroanisole | 448-19-1 |
| Brimonidine | 6-Amino-5-bromoquinoxaline | 50358-63-9 |
| Bupropion | 2-Bromo-3'-chloropropiophenone | 34911-51-8 |
| Cabozatinib | 1-(4-Fluorophenylcarbamoyl)Cyclopropanecarboxylic Acid 4-Hydroxy-6,7-dimethoxyquinoline 4-Chloro-6,7-dimethoxyquioline 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline | 849217-48-7 13425-93-9 35654-56-9 190728-25-7 |
| Canagliflozin | 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene 2-(5-Iodo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene | 1132832-75-7 1030825-20-7 1071929-08-2 898566-17-1 |
| Cevimeline | Spiro[1-Azabicyclo[2.2.2]octane-3,2'-oxirane] HCl | 64168-68-9 |
| Chlorthalidone | 2-(4-Chlorobenzoyl)benzoic acid 3-(4-Chlorophenyl)isoindolin-1-one | 85-56-3 2224-77-3 |
| Clobazam | Ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate 8-chloro-1-phenyl-1h-1,5-benzodiazepine-2,4(3h,5h)-dione | 22316-45-6 22316-55-8 |
| Cimicoxib | 3-Fluoro-4-methoxybenzaldehyde | 351-54-2 |
| Dapagliflozin, Empagliflozin, Ertugliflozin & Sotagliflozin | 5-Bromo-2-chloro-4'-ethoxydiphenylmethane 2-Chloro-5-iodo-4’-ethoxydiphenylmethane (5-bromo-2-chlorophenyl)(4’-ethoxyphenyl)methanone (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone 4-(5-Bromo-2-chlorophenyl)methyl]phenol 4-[(5-Iodo-2-chlorophenyl)methyl]phenol | 461432-23-5 1103738-29-9 461432-22-4 1103738-26-6 864070-18-8 1459754-32-5 |
| Delafloxacin | Azetidin-3-ol HCl | 18621-18-6 |
| Deracoxib | 3-Fluoro-4-methoxyacetophenone 4,4-Difluoro-1-(3-fluoro-4-methoxyphenyl)-1,3-butanedione | 455-91-4 170570-77-1 |
| Doxapram | N-Ethyl-3-Pyrrolidinol | 30727-14-1 |
| Droperidol | 1-Benzyl-3-carbethoxy-4-piperidone HCl | 1454-53-1 |
| Edoxaban | 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine 5-Methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridine-2-carboxylic acid HCl | 17899-48-8 720720-96-7 |
| Efinaconazole | 4-Methylene Piperidine Hydrochloride | 144230-50-2 |
| Efonidipine | 3-Amino-2-butenoic acid 2-(phenyl(phenylmethyl)amino)ethyl ester 3-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-buten-2-one 2-Acetonyl-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane | 111011-79-1 111011-78-0 111011-80-4 |
| Eltrombopag | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one (2-bromo-4-chloro-3-nitrophenyl) benzyl ether | 277299-70-4 18048-64-1 |
| Erdafitinib | 7-Bromoquinoxalin-2(1H)-one 7-Bromo-2-chloroquinoxaline | 82031-32-1 89891-65-6 |
| Esaxerenone | 4-(Methylsulfonyl)aniline HCl | 177662-76-9 |
| Felbamate | 2-Phenyl-1,3-propanediol | 1570-95-2 |
| Fimasartan | 2-(2-Butyl-4-Hydroxy-6-Methylpyrimidin-5-yl)-N,N-Dimethylacetamide 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide 2-butyl-1,6-dihydro-4-methyl-6-oxo-5-Pyrimidineacetic acid | 1315478-13-7 503155-67-7 1315478-16-0 |
| Firocoxib | 2-Bromo-2-methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone 2-Bromo-2-methyl-1-[4-(Methylthio)phenyl]-1-propanone 2-Hydroxy-2-methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone | 189955-79-1 88324-55-4 180048-73-1 |
| Flibanserin | 1-(1-Phenylvinyl)-1,3-dihydro-2H-benzimidazol-2-one 1-Isopropenyl-2-1,3-dihydro-2H-benzimidazol-2-one 1-[(3-Trifluoromethyl)phenyl]piperazine HCl 1-[(3-Trifluoromethyl)phenyl]piperazine | 60739-31-3 52099-72-6 16015-69-3 15532-75-9 |
| Fluralaner | 4-Acetyl-2-methylbenzoic acid | 55860-35-0 |
| Glycopyrronium Bromide | α-Cyclopentyl-DL-mandelic Acid N-Methyl-3-pyrrolidinol | 427-49-6 13220-33-2 |
| Ivabradine Hydrochloride | 3-(2-Bromo-4,5-dimethoxyphenyl)propionitrile 4,5-Dimethoxy-1-cyanobenzocyclobutane (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine HCl (3,4-Dimethoxy-bicyclo(4,2,0)octa-1(6),2,4-trien-7-ylmethyl)-carbamic acid ethyl ester (7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine HCl 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 7,8-Dimethoxy-1,3,4,5-tetrahydrobenzo[d]azepin-2-one 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one | 35249-62-8 35202-54-1 35202-55-2 148870-55-7 866783-13-3 73942-87-7 20925-64-8 85175-59-3 |
| Lenvatinib | 4-Chloro-7-Methoxyquinoline-6-carboxamide 4-Amino-3-chlorophenol 4-Amino-3-chlorophenol Hydrochloride | 417721-36-9 17609-80-2 52671-64-4 |
| Lercanidipine | N-Methyl-3,3-diphenylpropylamine 3,3-Diphenylpropylamine 2,6-Dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)1,4-dihydropyridine -3-carboxylic acid | 7250-67-1 5586-73-2 74936-72-4 |
| Letrozole | 4-(1H-1,2,4-Triazol-1-ylmethyl)benzonitrile | 112809-25-3 |
| Lobeglitazone | 4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzaldehyde 2-{[6-(4-Methoxyphenoxy)pyrimidin-4-yl]methylamino}ethanol | 607723-87-5 607723-69-3 |
| Luliconazole, Lanoconazole | 1-(Cyanomethyl)imidazole | 98873-55-3 |
| Mequitazine HCl | 3-Hydroxymethylquinclidine Hydrochloride 3-Hydroxymethylquinclidine 3-Chloromethylquinclidine Hydrochloride | 5176-22-7 |
| Mirtazapine | 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine | 61338-13-4 61337-89-1 |
| Mivacurium | 3,4,5-Trimethoxyphenylacetic acid 3,4-Dihydro-6,7-dimethoxy-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline | 951-82-6 61349-11-9 |
| Nateglinide | D-Phenylalanine methyl ester Hydrochloride | 13033-84-6 |
| Nintedanib | Methyl 2-Oxindoline -6-carboxylate 2-chloro N-methyl N-(4-nitro-phenyl) acetamide N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide Trimethyl orthobenzoate / Triethyl orthobenzoate | 14192-26-8 2653-16-9 1139453-98-7 262368-30-9 707-07-3 / 1663-61-2 |
| Olopatadine | 6,11-dihydro-11-oxodibenz(b,e)oxepin-2-acetic acid (isoxepac) 2-(4-Hydroxyphenyl)acetic acid methyl ester | 55453-87-7 14199-15-6 |
| Osimertinib | 3-(2-Chloro-4-pyrimidinyl)-1-methyl-1H-indole 5-Fluoro-2-nitroanisole 4-Fluoro-2-methoxy-5-nitroaniline N1,N1,N2-Trimethylethane-1,2-diamine | 1032452-86-0 448-19-1 1075705-01-9 142-25-6 |
| Ozenoxacin | 2-Amino-5-bromo-3-methylpyridine N-(5-Bromo-3-methyl-2-pyridinyl)-N-methylbenzamide 2,4-Dichloro-3-methylbenzoic acid 5-Bromo-N,3-dimethylpyridine-2-amine Ethyl 7-chloro-1-cyclopropyl-8-methyl -4-oxo-1,4-dihydroquinoline-3-carboxylate [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid | 3430-21 -5 446299-80-5 83277-23-0 245765-66-6 103877-51-6 446299-81-6 |
| Palbociclib , Ribociclib | Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 |
| Panobinostat | (E)-Methyl 3-(4-formylphenyl)acrylate 2-(2-Methyl-1H-indol-3-yl)ethanamine | 58045-41-3 08-06-2731 |
| Papaverine Hydrochloride | 3,4-Dihydropapaverine hydrochloride | 5884-22-0 |
| Pethidine ( Meperidine Hydrochloride) | 4-phenyl-1-tosylpiperidine-4-carbonitrile 4-phenyl-4-piperidinecarboxylic acid p-methyl benzene sulphonate 4-phenyl-1-tosylpiperidine-4-carboxylic acid 1-benzyl-4-phenylpiperidine-4-carbonitrile 1-benzyl-4-phenylpiperidine-4-carboxylic acid 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester | 24476-55-9 83949-32-0 84255-02-7 56243-25-5 61886-17-7 59084-08-1 |
| Phenotlamine mesylate | 2-(Chloromethyl)-4,5-dihydro-1H-imidazole HCl | 13338-49-3 |
| Pimavanserin Tartrate | N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidamine 1-[(4-(2-methylpropoxy)phenyl]methanamine | 359878-47-0 02-09-4734 |
| Pinaverium Bromide | 2-Bromo-4,5-dimethoxybenzyl bromide | 53207-00-4 |
| Primidone | 1-Phenyl-3-(piperidin-1-yl)propan-1-one HCl | 886-06-6 |
| Propiverine | N-Methyl-4-piperidyl benzilate | 3608-67-1 |
| Quetiapine | Dibenzo-[b,f][1,4]-thiazepine-11-[10H]-one 11-Piperazinodibenzo[b,f][1,4]thiazepine diHCl | 3159-07-7 111974-74-4 |
| Rilpivirine | (Cyanomethyl) triphenylphosphonium chloride (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile HCl | 4336-70-3 661489-23-2 |
| Rotigotine | 5-Methoxy-2-tetralone | 32940-15-1 |
| Rucaparib | Phthalimidoacetaldehyde | 2913-97-5 |
| Rupatadine | 5-Methyl-3-pyridinemethanol 3-Chloromethyl-5-methylpyridine HCl | 102074-19-1 1007089-84-0 |
| Selexipag | 5-Chloro-2,3-diphenylpyrazine 5,6-diphenylpyrazin-2(1H)-one 4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol Methansulfonamide | 41270-66-0 18591-57-6 475086-75-0 3144-09-0 |
| Stripentol | 4,4-Dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-one | 2419-68-3 |
| Suveroxant | 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid 5-Chlorobenzooxazole-2-thiol 2,5-Dichloro-1,3-Benzooxazole | 956317-36-5 22876-19-3 3621-81-6 |
| Tafamidis | 4-Amino-3-hydroxybenzoic acid | 2374-03-0 |
| Teneligliptin | (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butylester 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine | 401564-36-1 401566-79-8 |
| Tetrabenazine, Deutetrabenazine Valbenazine | 6,7-Dimethoxy-3,4-dihydroisoquinoline Hydrochloride 6,7-Dihydroxy-3,4-dihydroisoquinoline 1,2,3,4-tetrahydro isoquinoline-6,7-diol hydrobromide 3-((Dimethylamino)methyl)-5-methylhexan-2-one & oxalate salt (2-Acetyl-4-methylpentyl)trimethylammonium iodide | 20232-39-7 4602-83-9 52768-23-7 91342-74-4 1069-62-1 |
| Tivozanib | 4-Hydroxy-6,7-dimethoxyquinoline 4-Chloro-6,7-dimethoxyquioline | 13425-93-9 35654-56-9 |
| Tolmetin | Methyl-1-Methylpyrrole-2-acetate 1-Methyl-5-p-tolylpyrrole-2-acetic acid | 51856-79-2 26171-23-3 |
| Trialacilib | 5-(4-Methylpiperazin-1-yl)pyridin-2-amine | 571189-49-6 |
| Vilanterol trifenatate | Triphenylacetic acid | 595-91-5 |
| Vericiguat | Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate Ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile (E)-2-(Phenylazo)malononitrile | 256504-39-9 1361232-72-5 1361232-73-6 1350653-26-7 1350653-31-4, 6017-21-6 |
| Zaleplon | 3-Amino-4-Cyanopyrazole | 16617-46-2 |
| Ziprasidone, Lurasidone | 3-(1-Piperazinyl)-1,2-benzisothiazole / HCl 6-Chloro-2-oxindole 6-Chloro-5-(2-chloroacetyl)-2-oxindole 6-Chloro-5-(2-chloroethyl)-2-oxindole | 87691-87-0 / 87691-88-1 56341-37-8 118307-04-3 118289-55-7 |
| Zoledronc acid | Imidazol-1-yl acetic acid | 22884-10-2 |
| 2-Bromo-5-methylpyridine | 3510-66-5 | |
| 4-Iodo Phenylacetic acid | 1798-06-07 | |
| 4-Nitro Phenylacetic acid | 104-03-0 | |
| 4-Bromo Phenylacetic acid | 1878-68-8 | |
| 4-Mercaptophenylacetic acid | 39161-84-7 | |
| 2-Amino-5-bromopyridine | 1072-97-5 | |
| 5-Bromo-2-nitropyridine | 39856-50-3 | |
| 2-Thiophene carboxylic acid | 527-72-0 | |
| 4-Nitrobenzaldehyde | 555-16-8 | |
| 2,3-Dibromopyridine | 13534-89-9 | |
| Ethyl potassium malonate | 6148-64-7 | |
| Mono Ethyl malonate | 1071-46-1 | |
| 2-aminobenzyl alcohol | 5344-90-1 | |
| 5-Amino-2-methyl pyridine | 3430-14-6 | |
| α-Picolinic acid | 98-98-6 | |
| Thiosalicylic acid | 147-93-3 | |
| Pyridine N-Oxide | 694-95-7 | |
| Pyridine-4-aldehyde | 872-95-5 | |
| Methopabate Ethopabate | 4093-29-2 59-06-3 |
|
| Homoveratric acid | 93-40-3 | |
| 4-Hydroxyphenylacetic acid | 156-38-7 | |
| 4-Aminophenyl aceticacid | 1197-55-3 | |
| 1-(2-Chloroethyl)pyrrolidine HCl | 7250-67-1 | |
| 2-Acetylthiophene | 88-15-3 | |
| 2-Hydroxypyridine | 142-08-5 | |
| 2-Phenylacetophenone | 451-40-1 | |
| 2,3-Dibromopyridine | 13534-89-9 | |
| 2,4-Dichloropyrimidine | 3934-20-1 | |
| 2,5-Dibromopyridine | 624-28-2 | |
| N-Boc-piperazine | 57260-71-6 | |
| 1-Phenylpiperazine | 92-54-6 | |
| 1-(2-Pyridyl)piperazine | 34803-66-2 | |
| 1-(2-Pyrimidyl)piperazine HCl | 78069-54-2 | |
| 1-2-Methoxyphenyl piperazine | 35386-24-4 | |
| 1-2-Methoxyphenyl piperazine HCl | 5464-78-8 | |
| 2-(Aminomethyl)pyridine | 3731-51-9 | |
| 2-Aminobenzyl alcohol | 5344-90-1 | |
| 2-Hydroxypyridine | 142-08-5 | |
| 2-Hydroxypyrimidine HCl | 38353-09-02 | |
| 2,3-Diaminopyridine | 452-58-4 | |
| 2,3-Dibromopyridine | 13534-89-9 | |
| 2,5-Dibromopyridine | 624-28-2 | |
| 4-Aminobenzyl cyanide | 3544-25-0 | |
| 4-Hydroxybenzyl alcohol | 623-05-2 | |
| 4-Nitrobenzyl cyanide | 555-21-5 | |
| 5-Bromophthalide | 64169-34-2 | |
| Benzophenone imine | 1013-88-3 | |
| BOC Piperazine | 57260-71-6 | |
| Methyl 2-(4-Nitrophenyl)acetate | 2945-08-6 | |
| Thiophene-2-carboxylic acid | 527-72-0 |
